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Assesses the HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelets) using the Tennessee (Sibai) diagnostic criteria: hemolysis (LDH ≥ 600 U/L or schistocytes/low haptoglobin), AST ≥ 70 U/L, and platelets < 100,000/µL. HELLP is a severe form of preeclampsia with substantial maternal and fetal risk.
HELLP criteria: Hemolysis (LDH ≥ 600 U/L OR schistocytes/low haptoglobin) + Liver enzymes (AST ≥ 70 U/L) + Low platelets (< 100,000/µL); complete HELLP = all three present
Complete HELLP: all 3 criteria present; partial HELLP: 1–2 criteria present.
The Tennessee (Sibai) criteria define HELLP syndrome as hemolysis (abnormal peripheral smear with schistocytes, low haptoglobin, LDH ≥ 600 U/L, or total bilirubin > 1.2 mg/dL), elevated liver enzymes (AST ≥ 70 U/L), and low platelets (< 100,000/µL). Complete HELLP requires all three; patients with only some features are often labeled partial or atypical HELLP and managed similarly.
Specialty
ObstetricsCategory
Obstetrics & GynecologyDifficulty
Basic
Estimated Time
30 seconds
Version
1.0
Last Updated
2026-08-16
Formula
Keywords
Normal Range
Complete HELLP: all 3 criteria present; partial HELLP: 1–2 criteria present.
| Classification | Range |
|---|---|
None no HELLP features | 0 criteria |
Partial HELLP features present, not all | 1–2 criteria |
Complete HELLP all Tennessee criteria met | 3 criteria |
Assesses the HELLP syndrome using the Tennessee (Sibai) criteria: hemolysis (LDH ≥ 600 U/L or schistocytes/low haptoglobin), elevated liver enzymes (AST ≥ 70 U/L), and low platelets (< 100,000/µL); complete HELLP requires all three.
Complete HELLP requires all three Tennessee criteria (hemolysis, AST ≥ 70 U/L, platelets < 100,000/µL). Patients meeting only some criteria are classified as partial/atypical HELLP and are managed with the same vigilance because of the risk of rapid progression.
HELLP syndrome is a severe, rapidly progressive hypertensive disorder of pregnancy associated with maternal mortality from hepatic rupture, DIC, renal failure, and eclampsia; prompt recognition is life-saving.
A 32-week patient with preeclampsia and RUQ pain has platelets 95 ×10³/µL, AST 85 U/L, LDH 550 U/L, and schistocytes on the peripheral smear.
Inputs:
Complete HELLP syndrome — all three Tennessee criteria are met (hemolysis via smear evidence, AST ≥ 70, platelets < 100). Urgent delivery and multidisciplinary management are indicated.
Complete (classic) HELLP requires all three Tennessee criteria (hemolysis, AST ≥ 70, platelets < 100,000). Partial HELLP has one or two features; management is generally similar given the risk of progression.
Yes — up to 15–20% of patients do not have significant hypertension or proteinuria at presentation, which contributes to misdiagnosis.
Disclaimer: This calculator is intended for educational and clinical decision support purposes only. HELLP syndrome is a clinical emergency; laboratory-based scoring supplements, but does not replace, urgent clinical judgment.