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Calculates the albumin to globulin ratio from serum albumin and total protein (A/G ratio = albumin / (total protein − albumin)). The ratio is used as a screening aid in the evaluation of liver disease, nephrotic syndrome, and monoclonal gammopathies, alongside the absolute albumin and globulin values.
Globulin = Total protein − Albumin; A/G ratio = Albumin ÷ Globulin
1.0–2.0 (reference varies by laboratory)
The A/G ratio is a derived screening parameter from the basic metabolic chemistry panel and is most informative when the component values are reported together.
Specialty
Internal MedicineCategory
LaboratoryDifficulty
Basic
Estimated Time
30 seconds
Version
1.0
Last Updated
2026-08-16
Formula
Keywords
Normal Range
1.0–2.0 (reference varies by laboratory)
| Classification | Range |
|---|---|
Low typical adult reference | < 1.0 |
Normal typical adult reference | 1.0–2.0 |
High typical adult reference | > 2.0 |
Calculates the albumin to globulin (A/G) ratio from serum albumin and total protein to aid in evaluating liver disease, nephrotic syndrome, and paraproteinemias.
A typical adult A/G ratio is 1.0–2.0. A low ratio reflects either reduced albumin (liver disease, nephrotic syndrome, malnutrition) or elevated globulins (chronic inflammation, monoclonal gammopathy). Reference intervals vary by laboratory.
The A/G ratio is a simple derived parameter that flags globulin-predominant states, prompting the appropriate workup — liver and nutritional assessment for low albumin or serum protein electrophoresis for high globulins.
A 45-year-old man with suspected liver disease has serum albumin 4.0 g/dL and total protein 7.0 g/dL.
Inputs:
Globulin = 7.0 − 4.0 = 3.0 g/dL; A/G ratio = 4.0 ÷ 3.0 = 1.33 — normal.
A low ratio indicates globulin predominance — from reduced albumin (liver disease, nephrotic syndrome, malnutrition) or increased globulins (infection, autoimmune disease, multiple myeloma).
Yes. Concurrent low albumin and low globulin can produce a normal ratio despite significant hypoproteinemia, which is why the absolute values must always be reviewed together.
Cirrhosis staging
Disclaimer: This calculator is intended for educational and clinical decision support purposes only. Laboratory reference intervals vary; confirm with your local laboratory and interpret with clinical context.